Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection.

@article{Schwarz2012HepcidinIL,
  title={Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection.},
  author={Peggy Schwarz and Johanna A M K{\"u}bler and Pavel Strnad and Katrin B. M{\"u}ller and Thomas F E Barth and Andreas Gerloff and Peter Feick and Carole Peyssonnaux and Sophie Vaulont and Guido Adler and Hasan Kulaksiz},
  journal={Gut},
  year={2012},
  volume={61 2},
  pages={193-201}
}
BACKGROUNDS AND AIMS Hepcidin is an antimicrobial peptide and the central regulator of iron metabolism. Given that hepcidin was shown to be expressed in a variety of extrahepatic tissues and that stomach plays a role in iron absorption and in defence against infections, this study analysed the importance of hepcidin in the stomach. METHODS Expression and localisation of gastric hepcidin was studied by quantitative RT-PCR, western blot, immunofluorescence and in situ hybridisation. Regulation… CONTINUE READING
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