Hepcidin induces HIV-1 transcription inhibited by ferroportin

Abstract

Physiological regulation of cellular iron involves iron export by the membrane protein, ferroportin, the expression of which is induced by iron and negatively modulated by hepcidin. We previously showed that iron chelation is associated with decreased HIV-1 transcription. We hypothesized that increased iron export by ferroportin might be associated with… (More)
DOI: 10.1186/1742-4690-7-104

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