Hepcidin in beta-thalassemia.

@article{Nemeth2010HepcidinIB,
  title={Hepcidin in beta-thalassemia.},
  author={Elizabeta Nemeth},
  journal={Annals of the New York Academy of Sciences},
  year={2010},
  volume={1202},
  pages={31-5}
}
Iron overload is the principal cause of morbidity and mortality in beta-thalassemia with or without transfusion dependence. Iron homeostasis is regulated by the hepatic peptide hormone hepcidin. Hepcidin controls dietary iron absorption, plasma iron concentrations, and tissue iron distribution. A deficiency in this hormone is the main or contributing factor of iron overload in iron-loading anemias such as beta-thalassemia. Hepcidin deficiency results from a strong suppressive effect of the high… CONTINUE READING

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