Hepcidin expression in human airway epithelial cells is regulated by interferon-γ

@inproceedings{Frazier2011HepcidinEI,
  title={Hepcidin expression in human airway epithelial cells is regulated by interferon-γ},
  author={Marie D Frazier and Lisa B Mamo and Andrew J Ghio and Jennifer L. Turi},
  booktitle={Respiratory research},
  year={2011}
}
BACKGROUND Hepcidin serves as a major regulator of systemic iron metabolism and immune function. Airway epithelial cells have an extensive interface with the environment, and so must be able to respond locally to the presence of particulates, infection, and inflammation. Therefore, we hypothesized that hepcidin is expressed in airway epithelial cells and is regulated by early phase cytokines. METHODS Primary, differentiated human bronchial epithelial (NHBE) cells were used to assess hepcidin… CONTINUE READING