Hepcidin directly inhibits transferrin receptor 1 expression in astrocytes via a cyclic AMP‐protein kinase a pathway

@article{Du2011HepcidinDI,
  title={Hepcidin directly inhibits transferrin receptor 1 expression in astrocytes via a cyclic AMP‐protein kinase a pathway},
  author={Fang Du and Christopher Qian and Zhong Ming Qian and Xiao-mei Wu and Hui-Juan Xie and W. Yung and Y. Ke},
  journal={Glia},
  year={2011},
  volume={59}
}
Hepcidin, an iron‐regulatory hormone, plays a central role in iron homeostasis in peripheral tissues. The widespread distribution of hepcidin in the brain implies that the hormone may be essential for brain iron homeostasis. Here, we investigated the effects of hepcidin on the expression of iron uptake proteins, including transferrin receptor 1 (TfR1) and divalent metal transporter1 (DMT1) and the release protein ferroportin1 (Fpn1) in the cultured astrocytes. The effects of hepcidin on iron… Expand
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