Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis.

@article{Li2012HepcidinDA,
  title={Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis.},
  author={Juan Li and Xiao Meng and Hai Peng Si and Cheng Zhang and Hui Xia Lv and Yu Xia Zhao and Jian Yang and Mei Dong and Kai Zhang and Su Xia Liu and Xue Qiang Zhao and Fei Gao and Xiao Ling Liu and Tai Xing Cui and Yun Zhang},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2012},
  volume={32 5},
  pages={1158-66}
}
OBJECTIVE To explore a direct and causal relationship between vascular hepcidin and atherosclerotic plaque stability. METHODS AND RESULTS Accelerated atherosclerotic lesions were established by perivascular collar placement in apolipoprotein E-deficient (ApoE(-/-)) mice. Adenoviral overexpression of hepcidin in the carotid artery during plaque formation… CONTINUE READING