Hepcidin and its role in regulating systemic iron metabolism.

  title={Hepcidin and its role in regulating systemic iron metabolism.},
  author={Tomas Ganz},
  journal={Hematology. American Society of Hematology. Education Program},
  pages={29-35, 507}
  • Tomas Ganz
  • Published 2006 in
    Hematology. American Society of Hematology…
Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red cells in macrophages and from storage in hepatocytes. Moreover, during fetal development, the iron requirements of the fetus must be matched by the transport of maternal iron across the placenta. Hepcidin is a 25-amino acid disulfide-rich peptide synthesized in the liver that acts as a systemic iron-regulatory… CONTINUE READING