Hepcidin and Host Defense against Infectious Diseases

  title={Hepcidin and Host Defense against Infectious Diseases},
  author={Kathryn R. Michels and Elizabeta Nemeth and Tomas Ganz and Borna Mehrad and James B Bliska},
  booktitle={PLoS pathogens},
Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli. While the role of hepcidin in iron regulation is well established, its contribution to host defense is emerging as complex and multifaceted. In this review, we summarize the literature on the role of hepcidin as a mediator of antimicrobial immunity. Hepcidin induction during infection causes depletion of extracellular iron, which is… CONTINUE READING
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