Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

@inproceedings{Ding2011HepcidinII,
  title={Hepcidin Is Involved in Iron Regulation in the Ischemic Brain},
  author={Hui Ding and Cai-zhen Yan and Honglian Shi and Ya-Shuo Zhao and Shi-Yang Chang and Peng Yu and Wen-Shuang Wu and Chen-yang Zhao and Yan-Zhong Chang and Xiang-lin Duan},
  booktitle={PloS one},
  year={2011}
}
Oxidative stress plays an important role in neuronal injuries caused by cerebral ischemia. It is well established that free iron increases significantly during ischemia and is responsible for oxidative damage in the brain. However, the mechanism of this ischemia-induced increase in iron is not completely understood. In this report, the middle cerebral artery occlusion (MCAO) rat model was performed and the mechanism of iron accumulation in cerebral ischemia-reperfusion was studied. The… CONTINUE READING
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