Hepcidin: from discovery to differential diagnosis.

  title={Hepcidin: from discovery to differential diagnosis.},
  author={Erwin H. J. M. Kemna and Harold 4 Tjalsma and Hans L. Willems and Dorine W Swinkels},
  volume={93 1},
Although iron is essential for living organisms to survive, its reactive properties require strict regulation in order to prevent toxic effects. Hepcidin, a liver produced peptide hormone, is thought to be the central regulator of body iron metabolism. Its production is mainly controlled by the erythropoietic activity of the bone-marrow, the amount of circulating and stored body iron, and inflammation. Recent reports, however, provide new hypotheses on how hepcidin might exert its regulatory… CONTINUE READING

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