Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.

  title={Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.},
  author={T. Ganz},
  volume={102 3},
  • T. Ganz
  • Published 2003
  • Biology, Medicine
  • Blood
  • Human hepcidin, a 25-amino acid peptide made by hepatocytes, may be a new mediator of innate immunity and the long-sought iron-regulatory hormone. The synthesis of hepcidin is greatly stimulated by inflammation or by iron overload. Evidence from transgenic mouse models indicates that hepcidin is the predominant negative regulator of iron absorption in the small intestine, iron transport across the placenta, and iron release from macrophages. The key role of hepcidin is confirmed by the presence… CONTINUE READING
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