Hepatotoxicity related to antirheumatic drugs

  title={Hepatotoxicity related to antirheumatic drugs},
  author={Guruprasad P Aithal},
  journal={Nature Reviews Rheumatology},
Antirheumatic agents are among commonly used drugs associated with adverse hepatic reactions. Sulfasalazine and azathioprine are among the most important causes of acute hepatotoxicity. Because such a large number of people take NSAIDs, even the rare occurrence of hepatotoxicity from these agents might contribute substantially to the total burden of drug-induced liver disease. A wide spectrum of hepatotoxic effects is described with antirheumatic drugs. Studies investigating genetic… CONTINUE READING


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Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of reviews nrrheum_214_MAR11.indd

  • J Thibaudeau
  • Cancer Res
  • 2011

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

  • Singer, B J.
  • Nat. Genet
  • 2010

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