Hepatotoxicity of hydroxy-methyl-glutaryl-coenzyme A reductase inhibitors.

  title={Hepatotoxicity of hydroxy-methyl-glutaryl-coenzyme A reductase inhibitors.},
  author={Marco Ballar{\`e} and Mauro Campanini and Giuseppe Airoldi and Giuseppe Zaccala and M C Bertoncelli and Giuseppe Cornaglia and M. Porzio and A. Carrillo Monteverde},
  journal={Minerva gastroenterologica e dietologica},
  volume={38 1},
The first clinical studies on hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors reported a low incidence of liver toxicity. The personal observation of a case of simvastatin-induced acute cholestatic hepatitis prompted us to evaluate the true incidence of hepatic side effects of these drugs in a large Italian population. One hundred patients taking simvastatin and ninety patients treated with pravastatin were followed-up six months with periodical evaluation of serum lipid… CONTINUE READING

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