Hepatotoxicity of germander in mice.

@article{Loeper1994HepatotoxicityOG,
  title={Hepatotoxicity of germander in mice.},
  author={Jacqueline Robidaire Loeper and V{\'e}ronique Descatoire and Philippe Lett{\'e}ron and Claire Moulis and Claude Degott and Patrick M Dansette and Daniel Fau and Dominique Pessayre},
  journal={Gastroenterology},
  year={1994},
  volume={106 2},
  pages={
          464-72
        }
}
BACKGROUND/AIMS An epidemic of hepatitis due to germander teas or capsules recently occurred in France. The aim of the present study was to show the hepatotoxicity of germander and determine its mechanism in mice. METHODS A germander tea lyophilisate and a fraction that isolated and concentrated 10-fold the furano neo-clerodane diterpenoids of the lyophilisate were prepared. RESULTS (1) Intragastric administration of the lyophilisate (1.25 g/kg) or the furano neo-clerodane diterpenoid… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

Dictamnine-induced hepatotoxicity in mice: the role of metabolic activation of furan.

  • Toxicology and applied pharmacology
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity

  • International journal of molecular sciences
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Hepatotoxicity of herbal and dietary supplements: an update

  • Archives of Toxicology
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

Central role of mitochondria in drug-induced liver injury.

  • Drug metabolism reviews
  • 2012
VIEW 2 EXCERPTS
CITES BACKGROUND

Similar Papers