Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose.

@article{Hojo2000HepatotoxicityOA,
  title={Hepatotoxicity of acetaminophen and N-acetyl-p-benzoquinone imine and enhancement by fructose.},
  author={Minoru Hojo and Kenichi Hanioka and Masaaki Miyata and Y. Yamazoe},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2000},
  volume={30 9},
  pages={933-41}
}
1. Although oral administration of 400 mg/kg acetaminophen (APAP) or 1.8-3.4 g/kg sucrose had no effect on serum levels of alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH), their co-administration resulted in 20-fold increases in ALT/SDH activities. APAP alone (1250 mg/kg, p.o.) caused the elevation hepatotoxicity parameters, but the levels were lower than observed with co-administration of APAP (400 mg/kg) and sucrose (2.6 or 3.4 g/kg). 2. Sucrose-associated increase in serum… CONTINUE READING