Hepatotoxicity during rapid intravenous loading with amiodarone: Description of three cases and review of the literature.

@article{Bravo2005HepatotoxicityDR,
  title={Hepatotoxicity during rapid intravenous loading with amiodarone: Description of three cases and review of the literature.},
  author={Alexandra E R{\"a}tz Bravo and Juergen Drewe and Raymond Schlienger and Stephan Kr{\"a}henb{\"u}hl and Hans Pargger and Wolfgang C Ummenhofer},
  journal={Critical care medicine},
  year={2005},
  volume={33 1},
  pages={
          128-34; discussion 245-6
        }
}
OBJECTIVE Atrial fibrillation is the most common arrhythmia after cardiac surgery. Amiodarone can effectively prevent and control postoperative atrial and ventricular fibrillation. Acute hepatic damage after intravenous amiodarone, which can be fatal, is not well recognized. We describe three cases of acute hepatocellular injury after intravenous amiodarone administration in critically ill patients. Another 25 published cases and six cases reported to the Swiss Pharmacovigilance Center… CONTINUE READING
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