Hepatotoxicity and aging: endogenous antioxidant systems in hepatocytes from 2-, 6-, 12-, 18- and 30-month-old rats following a necrogenic dose of thioacetamide.

@article{Sanz2002HepatotoxicityAA,
  title={Hepatotoxicity and aging: endogenous antioxidant systems in hepatocytes from 2-, 6-, 12-, 18- and 30-month-old rats following a necrogenic dose of thioacetamide.},
  author={Nuria Mart{\'i}nez Sanz and Carmen D{\'i}ez-Fern{\'a}ndez and David Laje Andr{\'e}s and Mar{\'i}a Jos{\'e} Cordobilla Cascales},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1587 1},
  pages={
          12-20
        }
}
The influence of aging on the mechanisms of liver injury and regeneration was studied in a model of hepatotoxicity induced in 2-, 6-, 12-, 18- and 30-month-old rats by a sublethal dose of thioacetamide (500 mg/kg body weight), a soft nucleophilic and hepatotoxic compound metabolized by the hepatic microsomal FAD monooxygenase system. Samples-blood and hepatocytes-were obtained at 0, 12, 24, 48, 72 and 96 h following thioacetamide intoxication. Parameters of liver injury in serum (NADPH… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 39 CITATIONS

Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats.

  • Life sciences
  • 2012
VIEW 15 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

[Antioxidative abilities during aging].

  • Postepy higieny i medycyny doswiadczalnej
  • 2004
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The Role of Saikosaponins in Therapeutic Strategies for Age-Related Diseases

  • Oxidative medicine and cellular longevity
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND