Hepatosplenic gammadelta T-cell lymphoma after liver transplantation: report of the first 2 cases and review of the literature.

Abstract

Hepatosplenic gammadelta T-cell lymphoma is a rare lymphoproliferative disorder originating from natural killer-like Vdelta1-lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation. Both patients had thrombocytopenia with (hepato)splenomegaly but without peripheral lymphadenopathies and sinusoidal infiltration of the liver and spleen by monomorphic gammadelta-lymphocytes on pathological examination. The clinical and pathological findings, immunophenotypical profile, prognosis, and treatment are highlighted. In order to make an early diagnosis, physicians who take care of liver transplant recipients should be aware of the characteristic features of this posttransplant lymphoproliferative disorder. Therefore, a diagnostic algorithm is proposed.

DOI: 10.1002/lt.21748
01002003002011201220132014201520162017
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@article{Roelandt2009HepatosplenicGT, title={Hepatosplenic gammadelta T-cell lymphoma after liver transplantation: report of the first 2 cases and review of the literature.}, author={Philip R Roelandt and Johan A. Maertens and P Vandenberghe and Chris Verslype and Tania A D Roskams and Raymond Aerts and Frederik Nevens and Daan Dierickx}, journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society}, year={2009}, volume={15 7}, pages={686-92} }