Hepatoprotective effects of the nitric oxide donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats

@article{Salam2009HepatoprotectiveEO,
  title={Hepatoprotective effects of the nitric oxide donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats},
  author={Omar Mohamed E. Abdel Salam and Amany A. Sleem and N. Shafee},
  journal={Inflammopharmacology},
  year={2009},
  volume={18},
  pages={87-94}
}
  • Omar Mohamed E. Abdel Salam, Amany A. Sleem, N. Shafee
  • Published 2009
  • Chemistry, Medicine
  • Inflammopharmacology
  • The aim of this study was to investigate the effect of the nitric oxide donor isosorbide-5-mononitrate (5-ISMN) alone or in combination with the natural hepatoprotectant with anti-oxidant activity silymarin on the carbon tetrachloride (CCl4)-induced hepatic injury in rats. 5-ISMN (1.8, 3.6 or 7.2 mg/kg), silymarin (25 mg/kg) or 5-ISMN (1.8, 3.6 or 7.2 mg/kg) combined with silymarin was given once daily orally simultaneously with CCl4 and for 15 days thereafter. Liver damage was assessed by… CONTINUE READING
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