Hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries.

@article{Yoshitake1991HepatoprotectiveEO,
  title={Hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries.},
  author={I Yoshitake and Eiko Ohishi and Kazuhiro Kubo},
  journal={Japanese journal of pharmacology},
  year={1991},
  volume={57 2},
  pages={
          127-36
        }
}
Hepatoprotective effects of KF-14363 were investigated in the following experimental models. KF-14363 inhibited the increase in serum glutamate pyruvate transaminase (GPT) dose-dependently, and a significant inhibition was noted at a dose of 30 mg/kg or more. KF-14363 significantly inhibited the D-galactosamine (D-gal)-induced increase in serum transaminase by oral administration at 250 mg/kg x 1 and 250 mg/kg x 2 doses. The D-gal-induced decrease in total protein levels was inhibited at doses… 
Effects of 1-[(2-thiazolin-2-yl)amino]acetyl-4-(1,3-dithiol 2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) on liver regeneration and function of hepatic mitochondria in partially hepatectomized rats.
Effects of 1-[(2-Thiazolin-2-yl)amino]acetyl-4-(1,3-dithiol 2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363), a hepatoprotective compound, on liver regeneration, liver
Effects of KF-14363 on liver fibrosis in rats with chronic liver injury induced by carbon tetrachloride.
TLDR
The results show that KF-14363 inhibits liver fibrosis in a dose dependent fashion in rats with progressive liver injury.
Effect of an herbal protein, CI‐1, purified from Cajanus indicus, in models of liver failure in mice
TLDR
Treatment of severely liver‐injured mice with a protein, CI‐1, purified from the leaves of Cajanus indicus at a dose of 100 μg/ml i.p. regularly for 14 days significantly lowered the respective serum enzymes such as transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, and triglycerides, prevented the loss of liver protein content, and improved the altered plasma coagulability.
Effects of phenobarbital on drug metabolizing enzyme activities and other biochemical parameters in rats with DL-ethionine-induced liver injury.
TLDR
DME in the liver is induced by PB treatment in the ET-treated rats as well as in normal rats, and that the ET -treated rats have a function of physiological adaptation similar to that innormal rats.
Antioxidant and hepatoprotective activities of Cirsium setidens Nakai against CCl4-induced liver damage.
TLDR
The biochemical results were confirmed by histological observations indicating that C. setidens extract decreased ballooning degeneration in response to CCl(4) treatment, and it is suggested that the C. setsidens Extract has hepatoprotective effect related to its antioxidant activity.
Protective Effects of Radix Rosa laevigata against Propionibacterium acnes and Lipopolysaccharide-Induced Liver Injury
TLDR
The results suggest that the extract of R. R. laevigata offered good efficacy for preventing liver injury and the main peaks were identified as a series of polyphenol compounds which had been confirmed as the significantly active components by their anti-oxidative and NO inhibitory effects.
Antiulcer activity and subacute toxicity of trans-dehydrocrotonin from Croton cajucara
TLDR
The results suggest that the long-term use of this compound may induce liver damage, despite the beneficial antiulcerogenic activity of DHC.
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