Corpus ID: 55115816

Hepatoprotective effects of artichoke (Cynara scolymus)

  title={Hepatoprotective effects of artichoke (Cynara scolymus)},
  author={{\"O}. Aksu and B. Altınterim},
Artichoke has been used in traditional medicine for centuries as a specific liver and gallbladder remedy. The active ingredient in artichoke is cynarin which is found in highest concentrations in the leaves. Like silymarin, cynarin has demonstrated significant liver protecting and regenerating effects. 
Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity in mice
Artichoke and/or silymarin are suggested to protect against acetaminophen-induced hepatotoxicity in mice by ameliorating liver enzymes, antioxidant effect, decreasing liver damage and proliferation. Expand
Effects of biological fertilizers on some of the morphological and nutritional properties of globe artichoke
It was concluded that integrated plant nutrient treatments are more beneficial for the growth and quality of globe artichoke forage. Expand
After HCV Eradication with Sovaldiî, Can Herbs Regenerate Damaged Liver, Minimize Side Effects and Reduce the Bill?
A hypothesis is postulated for the possibility of the use of a herbal mixture of plants, known for their hepatoprotective activity, in a combination therapy with directly acting antiviral drugs such as Sovaldi® to help regenerate the liver, improve the clinical condition and reduce both the cost and side effects for hepatitis C virus patients. Expand
Effect of Chemical and Biological Fertilizers on Quantitative and Qualitative Yield of Artichoke (Cynara scolymus L.)
In order to evaluate the effect of different nutritional treatments on forage yield and some qualitative traits of artichoke (Cynara scolymus L.), an experiment was conducted as factorial experimentExpand
Influence of different levels of nitrogen fertilizer on some phytochemical characteristics of artichoke ( Cynara scolymus L . ) leaves
Based on the results, it is recommended to use 100 kg N ha when cultivating artichoke for its medicinal use and a positive correlation between the total phenol, total flavonoid content and antioxidant activity in artichokes is found. Expand
Effects of saline irrigated water on forage quality of globe artichoke (Cynara cardunculus var. scolymus L.)
Results showed that although increasing salinity decreased plant yield, it could increase forage quality characteristics and reduce NDF and ADF contents while ash, CP, DMD and TT contents were increased. Expand
Effects of water stress on growth parameters and forage quality of globe artichoke (Cynara cardunculus var. scolymus L.).
Although water stress decreased forage yield, it had a positive role in qualitative characteristics of Cynara forage due to the increase in CP, DMD and WSC along with the decrease in NDF, ADF and ash content. Expand
Efectos de los compuestos activos y funcionales de la alcachofa (Cynara cardunculus) en el control del metabolismo energético
RESUMEN ............................................................................................. 2 PARTE BIBLIOGRAFICAExpand


Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes.
The hepatoprotective activity against CCl4 toxicity in isolated rat hepatocytes of some polyphenolic compounds, such as cynarin, isochlorogenic acid, chlorogenic acid, luteolin-7-glucoside, and twoExpand
Globe artichoke: A functional food and source of nutraceutical ingredients
Artichoke by-products such as leaves, external bracts and stems that are produced by the artichoke processing industry, represent a huge amount of discarded material, which could be used as a source of inulin but also of phenolics, and should be considered as a raw material for the production of food additives and nutraceuticals. Expand
Efficacy of different Cynara scolymus preparations on liver complaints.
The results showed that the extract with the highest content in phenolic derivatives (GAE) exerted the major effect on bile flow and liver protection, and the results of the antioxidant capacity (BR) of the different preparations are in good agreement with the results obtained in vivo. Expand
In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats.
The in vitro protective activity of artichoke was confirmed in a rat model and its ability to alter in vivo antioxidative defense in male rats using selected biomarkers of antioxidant status was investigated. Expand
Comparison of choleretic effects of CYN and Na-dehydrocholate
L'attività coleretica, nel ratto, dell'ac. 1,4 dicaffeilchinico (Cinarina) risulta per dosi di 15–30 mg/kg per intensità e durata sovrapponibile a quella del Na-deidrocolato in dosi equimolecolari,Expand
Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves.
It is demonstrated that artichoke leaf extracts exert a potent anticholestatic action at least in the case of taurolithocholate, which may contribute to the overall hepatoprotective influence of this herbal formulation. Expand
Antioxidative and Apoptotic Properties of Polyphenolic Extracts from Edible Part of Artichoke (Cynara scolymus L.) on Cultured Rat Hepatocytes and on Human Hepatoma Cells
Findings indicate that AE had a marked antioxidative potential that protects hepatocytes from an oxidative stress and had an apoptotic activity on a human liver cancer cell line. Expand
Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes.
  • R. Gebhardt
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1997
It is demonstrated that artichoke extracts have a marked antioxidative and protective potential which was resistant against tryptic digestion, boiling, acidification, and other treatments, but was slightly sensitive to alkalinization. Expand
Stress-induced biosynthesis of dicaffeoylquinic acids in globe artichoke.
The development of an experimental system to induce caffeoylquinic acids may serve to study the regulation of the biosynthesis of (poly)phenolic compounds in globe artichoke and the genetic basis of this metabolic regulation. Expand