Hepatoprotective effects of Yulangsan flavone against carbon tetrachloride (CCl4)-induced hepatic fibrosis in rats.

@article{Guo2017HepatoprotectiveEO,
  title={Hepatoprotective effects of Yulangsan flavone against carbon tetrachloride (CCl4)-induced hepatic fibrosis in rats.},
  author={Youjia Guo and Xingmei Liang and Mingyu Meng and Hongxia Chen and Xiaojie Wei and Mingyan Li and Juman Li and Renbin Huang and Jinbin Wei},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2017},
  volume={33},
  pages={
          28-35
        }
}
  • Youjia Guo, Xingmei Liang, Jinbin Wei
  • Published 15 September 2017
  • Biology, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology

Figures and Tables from this paper

Effect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)
TLDR
Evaluated therapeutic effects of aqueous and ethanolic extracts of Trianthema portulacastrum against carbon tetrachloride (CCl4) induced toxicity in rabbits found that ethanolics extracts conferred hepato-protection on rabbits as silymarin did, suggesting that these extracts may be used instead of sily marin to improve animals health exposed to toxicity.
Camellia oil (Camellia oleifera Abel.) attenuates CCl4-induced liver fibrosis via suppressing hepatocyte apoptosis in mice.
TLDR
Results suggest that camellia oil attenuates CCl4-induced liver fibrosis in mice, and its mechanism may function via reduction of hepatocyte apoptosis to inhibit hepatic stellate cell (HSC) activation.
Efficiency of Sophora flavescens-Fructus Ligustri Lucidi Drug Pairs in the Treatment of Liver Fibrosis Based on the Response Surface Method
TLDR
The obtained results show that when the compatibility ratio of Sophora flavescens-Fructus Ligustri lucidi drug pairs is less than or equal to 1:1, their therapeutic effect is enhanced by synergy, which is stronger than that of the low-dose drug pairs.
Erythropoietin improves hepatic fibrosis via suppression of hepatic stellate cells and macrophage activation
TLDR
Data indicates that EPO has protective effects on CCl4 induced oxidative stress, inflammation, and liver fibrosis in rats, and suggests that the protective effects of rhEPO may be dependent on inhibition of HSCs and macrophage activation via Nrf2/HO-1 induction.
Anti-fibrotic activity of natural products, herbal extracts and nutritional components for prevention of liver fibrosis: review
TLDR
Natural products, herbal medicines and nutritional components that exhibited an anti-fibrotic activity through different mechanisms of action, including suppressing of cytokine production, inhibition of hepatic stellate cells “HSCs” propagation, modulation of the molecular mechanisms leading to hepatic fibrosis, free radical scavenging and anti-inflammatory properties are reviewed.
Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect
TLDR
It is demonstrated that PRAC-CDs can improve the body’s ability to scavenge oxygen free radicals and inhibit free radical-induced liver cell lipid peroxidation, thereby preventing liver cell damage, and significantly reduce MDA and increase SOD levels.
Quantification and Optimization of Ethanolic Extract Containing the Bioactive Flavonoids from Millettia pulchra Radix
TLDR
This research suggests an effective method, which will be helpful for quality control in the pharmaceutical development of this species, and develops and validate the HPLC-PDA method to determine their contents, and optimize its extraction.
Anti-inflammatory and antioxidative properties of helicid protect against CCl4 induced acute liver injury in mice
TLDR
The findings indicate that HEL protects against acute liver injury induced by CCl4, and appears to be due to its antioxidative and anti-inflammatory properties through the NF-κB signaling pathway.
Flavones as a Privileged Scaffold in Drug Discovery: Current Developments.
TLDR
The appearance of new catalysts and chemical transformations is expected to provide avenues for the synthesis of unexplored flavones, leading to the discovery of flavones with new properties and biological activities.
...
...

References

SHOWING 1-10 OF 47 REFERENCES
Mechanism of the Protective Effect of Yulangsan Flavonoid on Myocardial Ischemia/Reperfusion Injury in Rats
TLDR
The experiment showed that YLSF protected the heart against MI/RI, possibly by reducing lipid peroxidation damage, regulating NOS activity and modulating the apoptosis genes expression.
Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
  • Shuai ZhangBinan Lu Jinyong Peng
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats
TLDR
The data indicate that RLTS can be applied as one effective candidate for the treatment of liver fibrosis in the future, and indicates that RL TS markedly reduced cytochrome P450 2E1 activity, attenuated oxidative stress, and suppressed inflammation.
Protective effect of Yulangsan polysaccharide on focal cerebral ischemia/reperfusion injury in rats and its underlying mechanism.
TLDR
The YLS polysaccharide has a protective effect on cerebral ischemia/ reperfusion injury; the mechanism may be related to attenuating free radicals, and increasing the Bcl-2/Bax ratio.
Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro.
Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway.
Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model
TLDR
CCl4 activates tumor necrosis factor (TNF)alpha, nitric oxide (NO), and transforming growth factors (TGF)-alpha and -beta in the cell, processes that appear to direct the cell primarily toward (self-)destruction or fibrosis.
Potent effects of dioscin against liver fibrosis
TLDR
Dioscin exhibited potent effects against liver fibrosis through the modulation of multiple targets and signaling pathways and should be developed as a novel candidate for the treatment of Liver fibrosis in the future.
The Effects of 17-Methoxyl-7-Hydroxy-Benzene-Furanchalcone on the Pressure Overload-Induced Progression of Cardiac Hypertrophy to Cardiac Failure
TLDR
MHBFC protected the endothelium and prevented the pressure overload-induced progression of cardiac hypertrophy to cardiac failure, and partialy rescued the downregulated nitric oxide signaling system and inhibited the upregulated endothelin signaling system, normalizing the balance between these two systems.
...
...