Hepatoprotective effect of lucidone against alcohol-induced oxidative stress in human hepatic HepG2 cells through the up-regulation of HO-1/Nrf-2 antioxidant genes.

@article{Kumar2012HepatoprotectiveEO,
  title={Hepatoprotective effect of lucidone against alcohol-induced oxidative stress in human hepatic HepG2 cells through the up-regulation of HO-1/Nrf-2 antioxidant genes.},
  author={K Jayabal Senthil Kumar and J W Liao and Jun-Hong Xiao and M. Gokila Vani and Sheng-yang Wang},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2012},
  volume={26 5},
  pages={700-8}
}
Lucidone was previously reported to exhibit anti-inflammatory activity in vitro and in vivo. In the present study, we characterized the mechanisms underlying the hepatoprotective effect of lucidone against alcohol-induced oxidative stress in vitro. Human hepatoma (HepG2) cells were pretreated with lucidone (1-10μg/mL) and then hepatotoxicity was stimulated by the addition ethanol (100mM). With response to ethanol-challenge, increased amount of alanine aminotransferase (ALT) and aspirate… CONTINUE READING
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Anti - inflammatory effect of lucidone in mice via inhibition of NF - j B / MAP kinase pathway

  • K. J. S. Kumar, S. Y. Wang
  • Int . Immunopharmacol .
  • 2009
Highly Influential
6 Excerpts

Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2

  • S. B. Lee, C. Y. Kim, H. J. Lee, J. H. Yun, C. W. Nho
  • Planta Med
  • 2009
Highly Influential
3 Excerpts

Anti-inflammatory effect of lucidone in mice via inhibition

  • K.J.S. Kumar, H. W. Shei, S. Y. Wang
  • 2010
3 Excerpts

Generation of the heme oxygenase - 1 - transgenic rats

  • S. K. Das, S. Mukherjee, G. Gupta, D. N. Rao, D. M. Vasudevan
  • Exp . Biol . Med .
  • 2010
1 Excerpt

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