Hepatoprotective effect of kaempferol against alcoholic liver injury in mice.

@article{Wang2015HepatoprotectiveEO,
  title={Hepatoprotective effect of kaempferol against alcoholic liver injury in mice.},
  author={M. Wang and Jianguo Sun and Zhihui Jiang and Wenyan Xie and Xiaoying Zhang},
  journal={The American journal of Chinese medicine},
  year={2015},
  volume={43 2},
  pages={
          241-54
        }
}
Kaempferol is a biologically active component present in various plants. The hepatoprotective effect of kaempferol in drug-induced liver injury has been proven, while its effect against alcoholic liver injury (ALI) remains unclear. Hence, the present study aimed to evaluate the effect of kaempferol against ALI in mice. The experimental ALI mice model was developed and the mice were treated with different doses of kaempferol for 4 weeks. The liver functions were observed by monitoring the… 

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References

SHOWING 1-10 OF 45 REFERENCES

Protective Effects of Kaempferol on Isoniazid- and Rifampicin-Induced Hepatotoxicity

TLDR
To the authors' knowledge, this is the first report of kaempferol’s utility as an adjuvant for preventing CYP2E1-mediated hepatotoxicity induced by drugs such as INH and RIF.

Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats.

Enhancement by pyrazole of lipopolysaccharide‐induced liver injury in mice: Role of cytochrome P450 2E1 and 2A5

TLDR
Induction of CYP2E1 plays an important role in the enhancement of LPS liver injury by pyrazole, but some contribution by CYP1E1 cannot be excluded and CMZ protected against the pyrazoles enhanced L PS liver injury and oxidative stress.

Mitochondrial protective effects of Myrica rubra extract against acetaminophen-induced toxicity.

TLDR
The results showed that 50, 150, and 450 mg/kg MCE could restore AAP-induced changes in mice liver in a dose-dependent manner and the mechanisms behind the hepatoprotective effects of MCE may be related to the mitochondrial protection of liver cells, especially of VDAC, an important protein on the outer membrane of the mitochondria.

A review of natural products with hepatoprotective activity

TLDR
The present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin with hepatoprotective activity and intends to aid researchers in the study of natural products useful in the treatment of liver diseases.

CYP2E1: from ASH to NASH.

  • C. Lieber
  • Medicine
    Hepatology research : the official journal of the Japan Society of Hepatology
  • 2004

Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice.

  • J. BaiA. Cederbaum
  • Biology, Medicine
    Toxicological sciences : an official journal of the Society of Toxicology
  • 2006
TLDR
Results show that adenovirus-mediated overexpression of CYP2E1 could induce liver toxicity in mice and suggests a mechanism involving oxidative/nitrosative stress.

Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats.

TLDR
The low F of kaempferol is attributed in part to extensive first-pass metabolism by glucuronidation and other metabolic pathways in the gut and in the liver.