Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways

@article{Zaghloul2017HepatoprotectiveEO,
  title={Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways},
  author={R. A. Zaghloul and N. Elsherbiny and H. Kenawy and A. El-Karef and L. Eissa and M. El-Shishtawy},
  journal={Life Sciences},
  year={2017},
  volume={185},
  pages={114–125}
}
Aims: Wnt3a and Wnt5a are ligands orchestrating the canonical and non‐canonical pathways, respectively, with involvement in hepatocellular carcinoma (HCC). Hesperidin (HP) is a natural product found in citrus fruits and reputed for its antitumor activity. The present study aims to investigate the potential hepatoprotective effect of HP against thioacetamide (TAA)‐induced HCC focusing on its potential role on Wnt3a and Wnt5a signaling pathways. Main methods: Forty rats were equally divided into… Expand
Hesperidin suppressed hepatic precancerous lesions via modulation of exophagy in rats
Up-regulation of Wnt5a inhibits proliferation and migration of hepatocellular carcinoma cells
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