Hepatoprotective effect of grape seed proanthocyanidins on Cadmium-induced hepatic injury in rats: Possible involvement of mitochondrial dysfunction, inflammation and apoptosis

@inproceedings{Miltonprabu2016HepatoprotectiveEO,
  title={Hepatoprotective effect of grape seed proanthocyanidins on Cadmium-induced hepatic injury in rats: Possible involvement of mitochondrial dysfunction, inflammation and apoptosis},
  author={Selvaraj Miltonprabu and Nazimabashir and Vaihundam Manoharan},
  booktitle={Toxicology reports},
  year={2016}
}
The present study was undertaken to evaluate the possible ameliorative role of grape seed proanthocyanidins (GSP) against Cadmium (Cd) induced hepatic inflammation, apoptosis and hepatic mitochondrial toxicity in rats. Male Wistar rats were distributed in four experimental groups: control, GSP, Cd and Cd + GSP. Exposure to a hepatotoxic dose of Cd (5 mg/kg BW) caused liver damage, coupled with enhanced reactive oxygen species (ROS) generation, increased inflammation and apoptosis in liver with… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Protective role of grape seed proanthocyanidins against cadmium induced hepatic dysfunction in rats

  • V. Manoharan Nazimabashir, S. Milton Prabu
  • Toxicol . Res .
  • 2014

Ameliorative effect of aqueous curry leaf ( murraya koenigii ) extract against cadmium - induced oxidative stress in rat liver : involvement of antioxidant mechanisms

  • K. G. Arnab Elina, G. Debosree, +5 authors B. Debasish
  • Int . J . Pharm . Sci .
  • 2013

Similar Papers

Loading similar papers…