Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats.

@article{Mehrzadi2018HepatoprotectiveEO,
  title={Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats.},
  author={Saeed Mehrzadi and Iman Fatemi and Mahdi Esmaeilizadeh and Habib Ghaznavi and Hadi Kalantar and Mehdi Goudarzi},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2018},
  volume={97},
  pages={
          233-239
        }
}
Hepatotoxicity is one of the major side effects of methotrexate (MTX), which restricts the clinical use of this drug. Berberine (BBR) is a natural compound with multiple pharmacological activities such as antioxidant, antiapoptotic and anti-inflammatory effects. In this study, the effect of BBR on MTX-induced hepatotoxicity was studied. A total number of 28 male Wistar rats were randomly divided into four experimental groups. Rats were pretreated with BBR orally with dose of 100mg/kg for 10… Expand
The impact of Crocus sativus stigma against methotrexate-induced liver toxicity in rats
TLDR
The present findings provide showing CS could effectively alleviate MTX-induced hepatotoxicity in rats, and pre-and-post treatment with CS extract showed better protective effects than only post-treatment. Expand
Protective effect of inulin on methotrexate- induced liver toxicity in mice.
TLDR
The results revealed the new evidence that the hepatoprotective effects of inulin might be mediated via the modulations of apoptotic and oxidative stress factors. Expand
Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity.
TLDR
Results showed that MTX administration significantly increased ALP, ASP, ALT, MDA, NO, TNF-α, and IL-1β levels and significantly decreased antioxidant factors such as GSH, CAT, GPx, and SOD, which can prevent MTX-induced hepatotoxicity through mitigation of oxidative stress and inflammation. Expand
Hepatorenal protective effects of protocatechuic acid in rats administered with anticancer drug methotrexate
TLDR
Administration of PCA markedly abated MTX-induced increases in interleukin-1β, tumor necrosis factor alpha, and caspase 3 activity in the rats, and biochemical data on the hepatorenal protective effects ofPCA were well supported by the histological data. Expand
THE PROTECTIVE EFFECTS OF ECHINOPS HETEROPHYLLUS EXTRACT AGAINST METHOTREXATE-INDUCED HEPATOTOXICITY IN RABBITS
Objective: The aim of this study was to investigate antioxidant and hepatoprotective properties of Iraqi Echinops heterophyllus aqueous crude extract and its flavonoid fraction against methotrexateExpand
Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats.
TLDR
By increasing antioxidant defense in hepatic tissues and reducing oxidative stress and proinflammatory mediators, pretreatment with CRO could alleviate MTX-induced hepatotoxicity. Expand
Antioxidant and hepatoprotective property of squalene for counteracting the oxidative damage induced by methotrex- ate in experimental rats
Methotrexate (MTX), an antifolate drug, is extensively prescribed for patients suffering from diseases like cancer, psoriasis, neoplasms, and rheumatoid arthritis. Despite its effectiveness, MTXExpand
Potential Therapeutic Activities of Melatonin and Alpha Lipoic Acid on Methotrexate-Induced Hepatotoxicity in Rats
The search for newer and better hepatoprotective agents is imperative so as to alleviate the socio-economic burden of hepatotoxicity caused by MTX. This study investigated the protective effects ofExpand
Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells
TLDR
MTX and Nar are introduced as promising antiproliferative agents with a distinctive mode of action, inducing apoptosis in HepG2 tumor cells through activation of Bax and down-regulation of Bcl-2 protein expression. Expand
Protective and Therapeutic Effects of Quercetin on Methotrexate Induced Hepatotoxicity in Adult Albino Rats: Biochemical, Histological and Immunohistochemical Study
Background: Methotrexate(Mtx) is an antineoplastic and immunosuppressive drug. That may cause hepatotoxicity, whereas quarcetin has anti-inflammatory and antiproliferativeproperties. Aim of the Work:Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Protective effect of berberine on doxorubicin‑induced acute hepatorenal toxicity in rats.
TLDR
Results suggested that pretreatment with Ber ameliorated the DOX‑induced liver and kidney injury by lowering the serum ALT, AST, TCHO and BUN levels, and the damage observed histologically, such as hemorrhage and focal necrosis of liver and kidneys tissues induced by DOX were also attenuated by Ber. Expand
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.
TLDR
It is suggested that ALA and PTX can have protective effects by decreasing MDA, NO, BUN and urea values as antioxidants against MTX-induced damage in liver and kidney of rats. Expand
Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach.
TLDR
Findings demonstrated the hepatoprotective nature of CGA by attenuating the pro-inflammatory and apoptotic mediators and improving antioxidant competence in hepatic tissue and imply that CGA has perfective effect against MTX-induced liver injury. Expand
Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats
TLDR
Berberine possesses hepatoprotective effects against CCl4-induced hepatotoxicity and that the effects are both preventive and curative, demonstrates that berberine should have potential for developing a new drug to treat liver toxicity. Expand
Melatonin-lycopene combination improves methotrexate-induced liver toxicity in rats via anti-inflammatory effect
TLDR
The LYC-MLT combination improved the acute toxic effects of MTX on the liver, and improved both liver function and the histopathology level, but oxidative stress parameters such as TOS and OSI did not change in MIT. Expand
Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis
TLDR
Results suggest that Chrysin has a protective effect against hepatotoxicity induced by MTX and it may, therefore, improve the therapeutic index of MTX if co-administration is done. Expand
Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice
TLDR
The results revealed that MEL might be useful for prevention of the nephrotoxicity induced by CP through ameliorative effects on biochemical indices and oxidative stress parameters. Expand
Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction
TLDR
Berberine exerts renoprotective effects through its anti-oxidant, anti-inflammatory, and anti-apoptotic properties through the protective effect of berberine against GM-induced nephrotoxicity and possible underlying mechanisms. Expand
Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats.
TLDR
MTX-induced structural and functional damage to hepatic tissues in rats may involve oxidative stress, and cytoprotective agents (NAC > AMF > ASC) may alleviate MTX hepatotoxicity. Expand
Comparison of the effect of vanadium and deferoxamine on acetaminophen toxicity in rats
TLDR
It was observed that vanadium had better effect than deferoxamine in the prevention of hepatotoxicity induced by APAP and also kidney function during APAP administration in rats. Expand
...
1
2
3
4
...