Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by L-NAME in rats.

@article{Souza2012HepatoprotectiveAA,
  title={Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by L-NAME in rats.},
  author={Camila O Souza and Maria Terezinha S Peracoli and Ingrid Cristina Weel and Camila Ferreira Bannwart and Mariana Fadil Rom{\~a}o and Erika Nakaira-Takahagi and Leonardo Teixeira Lopes de Medeiros and M{\'a}rcia Guimar{\~a}es da Silva and Jos{\'e} Carlos Peraçoli},
  journal={Life sciences},
  year={2012},
  volume={91 5-6},
  pages={159-65}
}
AIMS Inhibition of nitric oxide synthase with N-omega-nitro-l-arginine methyl ester (l-NAME) has been employed as an experimental model of human preeclampsia. This study determined the protective effect of silibinin, a flavonoid with anti-inflammatory and hepatoprotective properties on the deleterious effects observed in experimentally induced preeclampsia in rats. MAIN METHODS Pregnant Wistar rats were treated during gestation (days 10-20) with l-NAME (70-80mg/kg/day) in drinking water or… CONTINUE READING
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  • RS Moura, AC Resende, AS Moura, MF. Maradei
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