Hepatoprotective and anti-fibrotic functions of interleukin-22: therapeutic potential for the treatment of alcoholic liver disease.

@article{Kong2013HepatoprotectiveAA,
  title={Hepatoprotective and anti-fibrotic functions of interleukin-22: therapeutic potential for the treatment of alcoholic liver disease.},
  author={Xiaoni Kong and Dechun Feng and Stephanie A Mathews and Bin Gao},
  journal={Journal of gastroenterology and hepatology},
  year={2013},
  volume={28 Suppl 1},
  pages={
          56-60
        }
}
Interleukin-22 (IL-22) plays a key role in promoting antimicrobial immunity and tissue repair at barrier surfaces by binding to the receptors IL-22R1, which is generally thought to be expressed exclusively in epithelial cells, and IL-10R2. Our laboratory previously demonstrated that IL-22 plays an important role in ameliorating liver injury in many rodent models by targeting hepatocytes that express high levels of IL-22R1 and IL-10R2. Recently, we have identified high expression levels of IL… CONTINUE READING