Hepatoprotective activity of Clearliv a polyherbal formulation in Wistar rats

@article{Kumar2013HepatoprotectiveAO,
  title={Hepatoprotective activity of Clearliv a polyherbal formulation in Wistar rats},
  author={Ep Kumar and V. Rele Rajan and Anil Kumar and Subramani Parasuraman and Sf Emerson},
  journal={Archives of Medicine and Health Sciences},
  year={2013},
  volume={1},
  pages={120 - 125}
}
Objective: To evaluate the hepatoprotective activity of Clearliv a polyherbal formulation in Wistar rats. Materials and Methods: The hepatoprotective potential of Clearliv was evaluated in thioacetamide-induced liver necrosis, DL-galactosamine [GalN]-induced liver injury, and carbon tetrachloride [CCl 4 ]-induced hepatitis models in Wistar rats. In all the models, Clearliv (at the dose levels of 800, and 1000 mg/kg) was administered for 3 days orally followed by single intraperitoneal… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Hepatoprotective and behavioral effects of jigrine in galactosamine-induced hepatopathy in rats
TLDR
The hepatoprotective activity of jigrine, a polypharmaceutical herbal formulation, at a dose of 1 mL/kg/day p.o. was evaluated against galactosamine-induced hepatopathy in rats to assess liver function and d-Gal-induced elevation in serum levels of ALT, ALP, and bilirubin was significantly reduced. Expand
Hepatoprotective and antioxidant activity of Phaseolus trilobus, Ait on bile duct ligation induced liver fibrosis in rats.
TLDR
Two extracts of Phaseolus trilobus were found to reduce the elevated levels of serum thiobarbituric acid reactive substance and elevate superoxide scavenging radical activity proving antioxidant activity comparable with ascorbic acid. Expand
Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo.
TLDR
Results suggested that intraperitoneal administration of the extract could protect liver from NIM-induced hepatic damage more effectively than oral administration and Antioxidant property of the aqueous extract of PN was also compared with that of a known potent antioxidant, vitamin E. Expand
Role of carnosine in preventing thioacetamide-induced liver injury in the rat
TLDR
The findings indicate that carnosine, in vivo may have a preventive effect on TAA-induced oxidative stress and hepatotoxicity by acting as an non-enzymatic antioxidant itself. Expand
Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1.
TLDR
Findings indicate that hepatic CYP2E1 appears to be primarily involved in bioactivation of TA, which is likely to mediate the potentiated TA hepatotoxicity in diabetic rats. Expand
Protective and Therapeutic Effect of the Indonesian Medicinal Herb Curcuma xanthorrhiza on β‐D‐Galactosamine‐induced Liver Damage
TLDR
The results clearly indicated that the extract of C. xanthorrhiza significantly reduced the acute elevation of serum transaminases induced by hepatotoxin, and alleviated the degree of liver damage at 24 h after the intraperitoneal administration of the hepatotoxins. Expand
Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats.
TLDR
It is suggested that eugenol curtails the toxic effects of TA in liver by decreasing CYP2E1 activity, lipid peroxidation indices, protein oxidation and inflammatory markers and by improving the antioxidant status. Expand
Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats.
TLDR
It is shown that LFS and APS display hepatoprotective and antioxidant properties and act in a synergistic manner in CCl(4) induced liver injury in rats. Expand
Phenobarbital pretreatment increases thioacetamide induced necrosis and post- necrotic regeneration in rats
One of the most important events related to drug interactions is the ability of some drugs to induce hepatic microsomal monooxygenases and to increase the toxicity of other drugs. A single… Expand
Effect of HD-03--a herbal formulation in galactosamine-induced hepatopathy in rats.
TLDR
HD-03 provided convincing evidence of hepatoprotection against galactosamine induced hapatotoxicity in rats, and was compared against untreated group for SGPT, SGOT, serum bilirubin and liver glycogen. Expand
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