Hepatoprotective action of prostaglandin A(2) analogs under CCl(4)-induced liver injury in vitro.

@article{Hubich2007HepatoprotectiveAO,
  title={Hepatoprotective action of prostaglandin A(2) analogs under CCl(4)-induced liver injury in vitro.},
  author={Aksana I Hubich and Alexey Y Bondar and Tatsiana U Kastsiuk and Uladimir A Kastsiuk and Fyodar A Lakhvich and Mikhail V. Sholukh},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2007},
  volume={37 6},
  pages={416-24}
}
AIM The cytoprotective effects of six novel synthetic prostaglandin A(2) analogs against carbon tetrachloride (CCl(4)) as a toxic agent were studied with isolated rat liver hepatocytes in vitro. RESULTS It was found that hepatocytes treatment with CCl(4) induced: (i) a significant increase of lactic dehydrogenase (LDH) release from cytoplasm; (ii) leakage of glutamate dehydrogenase (GDH) and acid phosphatase from mitochondria and lysosomes, respectively; (iii) 10-fold increase of trien… CONTINUE READING