Hepatoprotective Effect of a Hot-Water Extract from the Edible Thorny Oyster Spondylus varius on Carbon Tetrachloride-Induced Liver Injury in Mice

@article{Koyama2006HepatoprotectiveEO,
  title={Hepatoprotective Effect of a Hot-Water Extract from the Edible Thorny Oyster Spondylus varius on Carbon Tetrachloride-Induced Liver Injury in Mice},
  author={Tomoyuki Koyama and Ritsu Chounan and Daisuke Uemura and Kohji Yamaguchi and Kazunaga Yazawa},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2006},
  volume={70},
  pages={729 - 731}
}
The edible thorny oyster, Spondylus varius (Mizuiri-shoujou), was found to suppress the carbon tetrachloride-induced increase in serum aspartate and alanine aminotransferase activities in mice. Significant suppressive effects on these enzyme activities were found in the fraction eluted with 75% ethanol from polystyrene gel in a dose-dependent manner. These results suggest that S. varius exerts a protective effect against liver injury. 
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Citation Type

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Present treatment showed that both the oyster and reishi has significantly inhibited the rise of both serum liver enzymes in the treated mice compared to controls, and lipid profile significantly reduced after 24 hours by the intraperitoneal administration of these extracts.
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Curative effect of the Egyptian marine Erugosquilla massavensis extract on carbon tetrachloride-induced oxidative stress in rat liver and erythrocytes.
  • S. Fahmy, S. Hamdi
  • Biology
    European review for medical and pharmacological sciences
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The results of the present study suggested that, the MCE could protect the liver and erythrocytes injuries perhaps, by its antioxidative effect, hence eliminating the deleterious effect of toxic metabolites from CCl4.
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Oyster mushroom can protect liver tissue against paracetamol induced liver damage, and is considered as hepatoprotective agent in rats.
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