• Corpus ID: 212555209

Hepatoprotective And Antioxidant Activity Of Ethanol Extract Of Mentha arvensis Leaves Against Carbon Tetrachloride Induced Hepatic Damage In Rats

@inproceedings{Rajesh2013HepatoprotectiveAA,
  title={Hepatoprotective And Antioxidant Activity Of Ethanol Extract Of Mentha arvensis Leaves Against Carbon Tetrachloride Induced Hepatic Damage In Rats},
  author={Kowti Rajesh and A.H.M. Viswanatha Swamy and Shakira A. Inamdar and Vedamurthy Joshi and Abdul Nasir Kurnool},
  year={2013}
}

• K. Rajesh, A. V. Swamy, +2 authors Abdul Nasir Kurnool
• Published 2013

The aim of the study is to investigate the ethanol extract of Mentha arvensis leaves were screened for its hepatoprotective and antioxidant activities in CCl4 (1 ml/kg bw) induced hepatic damage in rats. The extracts at doses of 100, 200 and 400 mg/kg bw were administered orally once daily for five days. The extract of M. arvensis decreases the elevated levels of serum biochemical markers aspartate aminotransferase (AST), alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Total and direct bilirubin. The antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) significantly increased and MDA level significantly decreased in extract treated groups. Silymarin (50 mg/kg) was used as standard and exhibited significant hepatoprotective activity. The results of this study strongly indicate that Mentha arvensis leaves have potent hepatoprotective action at the dose of 400 mg/kg bw.