Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.

Abstract

Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transporter genes involved in promoting bile acid clearance and… (More)

Topics

6 Figures and Tables

Cite this paper

@article{Liu2003HepatoprotectionBT, title={Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.}, author={Yaping Liu and Jane G Binz and Mary Jo Numerick and Steve Dennis and Guizhen Luo and Bhasha Desai and K I Mackenzie and Traci A. Mansfield and Steven A. Kliewer and Bryan J Goodwin and Stacey A. Jones}, journal={The Journal of clinical investigation}, year={2003}, volume={112 11}, pages={1678-87} }