Corpus ID: 19268545

Hepatoprotection by 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one against experimentally induced liver injury in rats.

  title={Hepatoprotection by 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one against experimentally induced liver injury in rats.},
  author={B. Tripathi and Savita Srivastava and R. Rastogi and D. Raina and V. Ram and A. Srivastava},
  journal={Acta pharmaceutica},
  volume={53 2},
Hepatoprotective activity of 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one, an isostere of dimethyl ricinine, was evaluated in adult male albino rats intoxicated with carbon tetrachloride, paracetamol or thioacetamide. The test compound showed significant hepatoprotection at 6.0 mg kg(-1) body mass daily dose, given to the rats for seven consecutive days. The carbon tetrachloride, paracetamol and thioacetamide were given, respectively, on days 3, 5, and 7, on day 6 and on day 6 post… Expand
Antifibrotic Effect of Curcumin on Thioacetamide Induced Liver Fibrosis
TThe objective of the present study was to elucidate whether serum ATX activity might be a target for regulation of liver fibrosis and to evaluate the hepatoprotective and antifibrotic effect ofExpand
Attenuating Effect of Ginkgo biloba Leaves Extract on Liver Fibrosis Induced by Thioacetamide in Mice
  • A. M. Al-Attar
  • Chemistry, Medicine
  • Journal of biomedicine & biotechnology
  • 2012
This study showed that Ginkgo biloba leaves extract has a potential activity against TAA-induced liver fibrosis and suggested that the chemical constituents of G. biloba are effective in modulation of oxidative stress induced by TAA. Expand
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Results suggested that the effect of extracts of olive and rosemary leaves might be due to their antioxidant activities against TAA toxicity, and improved the physiological disturbances induced by TAA intoxication. Expand
A Review on Drug Induced Hepatotoxicity and Alternative Therapies
This review provides up-to-date information about drug-induced hepatotoxicity and hepatoprotective effects of different interventions (Nutritional supplements, Medicinal plants and Herbal formulations) for liver disease or hepatot toxicity. Expand
Effect of prenatal and perinatal acrylamide on the biochemical and morphological changes in liver of developing albino rat
Prenatally and perinatally administered acrylamide significantly increased lipid peroxidation and reduced glutathione and total thiol levels in liver and serum and the most noticeable change was splitting of β-globulin into β1- and β2- globulins. Expand
Herbs as liver savers - a review.
Herbal medicines are in great demand in the developed world for primary health care due their efficacy, safety and lesser side effects. Recently, considerable attention has been paid to utilizeExpand
Medicinal significance, pharmacological activities, and analytical aspects of ricinine: A concise report
This work is supported by University Grant Commision, New Delhi, India with grant No: IT/DEV/08-09/3252/L. Expand
Estudio Cinético de la Descomposición Térmica de Tres Derivados del Pirano (C5H6O)
Resumen El articulo presenta el estudio cinetico de descomposicion termica de tres compuestos derivados del pirano que no han sido reportados en la literatura. Estos compuestos son ampliamenteExpand