Hepatoma with severe non-islet cell tumor hypoglycemia

  title={Hepatoma with severe non-islet cell tumor hypoglycemia},
  author={Uwe J. F. Tietge and Christof Sch{\"o}fl and Kenneth W Ocran and Siegfried Wagner and Klaus H.W. Boeker and Georg Brabant and Juergen Zapf and Michael P. Manns},
  journal={American Journal of Gastroenterology},
We report a 22-yr-old male patient with chronic hepatitis B and a large, well differentiated hepatoma who developed episodes of symptomatic fasting hypoglycemia, which were caused by paraneoplastic secretion of unprocessed “big” insulin-like growth factor-II. Initially, the patient presented with normal liver function, which deteriorated during the clinical course. Therapeutic attempts to reduce tumor mass failed and the patient subsequently died because of metastases of the hepatoma. The… CONTINUE READING


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