Hepatoma-derived growth factor regulates the bad-mediated apoptotic pathway and induction of vascular endothelial growth factor in stomach cancer cells.

@article{Lee2010HepatomaderivedGF,
  title={Hepatoma-derived growth factor regulates the bad-mediated apoptotic pathway and induction of vascular endothelial growth factor in stomach cancer cells.},
  author={Kyung Hee Lee and Eun Young Choi and Min Kyoung Kim and Si Hyung Lee and Byung Ik Jang and Tae Nyeun Kim and Se Won Kim and Sang Woon Kim and Sun Kyo Song and J W Kim and Bo Chan Jung},
  journal={Oncology research},
  year={2010},
  volume={19 2},
  pages={67-76}
}
Hepatoma-derived growth factor (HDGF) is highly expressed in tumor cells and may play an important role in the development and progression of carcinomas. However, the molecular mechanism by which HDGF participates in gastric carcinomatosis requires further analysis. In this study, we determined the role of HDGF in tumorigenesis and elucidated the mechanisms of action. To determine aggressive biological behavior, we knocked down HDGF expression with HDGF-specific shRNA in two gastric cancer cell… CONTINUE READING
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