Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial--mesenchymal transition.

@article{Chen2012HepatomaderivedGF,
  title={Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial--mesenchymal transition.},
  author={San-Cher Chen and Mei-Lang Kung and Tsung-Hui Hu and Hsuan-Yu Chen and Jian-Ching Wu and Hsiao-Mei Kuo and Han-En Tsai and Yu-Wei Lin and Z F Wen and Jong-kang Liu and Ming-Hsin Yeh and Ming-Hong Tai},
  journal={The Journal of pathology},
  year={2012},
  volume={228 2},
  pages={158-69}
}
Hepatoma-derived growth factor (HDGF) participates in tumourigenesis but its role in breast cancer is unclear. We set out to elucidate the expression profile and function of HDGF during breast carcinogenesis. Immunoblot and immunohistochemical studies revealed elevated HDGF expression in human breast cancer cell lines and tissues. Nuclear HDGF labelling index was positively correlated with tumour grade, stage and proliferation index, but negatively correlated with survival rate in breast cancer… CONTINUE READING