Hepatoma-derived growth factor is a neurotrophic factor harbored in the nucleus.

@article{Zhou2004HepatomaderivedGF,
  title={Hepatoma-derived growth factor is a neurotrophic factor harbored in the nucleus.},
  author={Zhiwei Zhou and Yoichi Yamamoto and Fuminobu Sugai and Kenya Yoshida and Yoshihiko Kishima and Hisae Sumi and Hideji Nakamura and Saburo Sakoda},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 26},
  pages={27320-6}
}
Hepatoma-derived growth factor (HDGF) is a heparin-binding proliferating factor originally isolated from conditioned medium of the hepatoma-derived cell line HuH-7. HDGF has greatest homology in an amino acid sequence with high mobility group 1 (HMG1), which has been characterized as a DNA-binding, inflammatory, and potent neurite outgrowth molecule. HDGF is reported to be widely expressed and act as a growth factor in many kinds of cells. However, it has not been investigated in the nervous… CONTINUE READING

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