Hepatoma-derived growth factor as a prognostic marker in completely resected non-small-cell lung cancer.

@article{Iwasaki2005HepatomaderivedGF,
  title={Hepatoma-derived growth factor as a prognostic marker in completely resected non-small-cell lung cancer.},
  author={Teruo Iwasaki and Katsuhiro Nakagawa and Hideji Nakamura and Yoshiaki Takada and Kaoru Matsui and Kunimitsu Kawahara},
  journal={Oncology reports},
  year={2005},
  volume={13 6},
  pages={1075-80}
}
Hepatoma-derived growth factor (HDGF), unrelated to hepatocyte growth factor, is a heparin-binding protein originally purified from human hepatoma HuH-7 cells. HDGF exhibits mitogenic activities for certain hepatoma cells, fibroblasts and vascular smooth muscle cells, and angiogenic activities through nuclear targeting. Recently, HDGF was found to be a mitogen for lung epithelial cells in vitro and in vivo. This suggests that HDGF may play a critical role in the development and progression of… CONTINUE READING