Hepatocytic gene expression in cultured rat mesenchymal stem cells.

  title={Hepatocytic gene expression in cultured rat mesenchymal stem cells.},
  author={Claudia Lange and Philipp Bassler and Michael V Lioznov and Helge Bruns and Dietrich Kluth and Axel Rolf Zander and Henning Cornelius Fiegel},
  journal={Transplantation proceedings},
  volume={37 1},
The origin of liver cells from distinct bone marrow stem cells, eg, hematopoietic stem cells or multipotent adult progenitor cells has been recently described using in vitro studies. Cell culture experiments revealed the key role of growth factors and the organ-specific environment for the induction of liver-specific genes. We investigated the in vitro potential of rat mesenchymal stem cells to differentiate into hepatocytic cells in cocultures with isolated rat liver cells. Rat mesenchymal… CONTINUE READING


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