Hepatocytes modulate the hepatic microvascular phenotype.

  title={Hepatocytes modulate the hepatic microvascular phenotype.},
  author={L{\'a}szl{\'o} M{\'o}dis and Antonio Martinez-Hernandez},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={65 6},
The liver microvasculature is unique among epithelial organs because it is composed of sinusoids rather than capillaries. Since hepatocytes lack a basement membrane, they are not separated from plasma by any continuous filtration barrier. During the cirrhotic process, the sinusoids become transformed into typical continuous capillaries with specialized endothelial junctions, continuous basement membrane, and pericytes. To explore the factors that determine the phenotype of the hepatic… CONTINUE READING
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