Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity.

@article{Zheng1996HepatocytesFM,
  title={Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity.},
  author={Hong-jun Zheng and Jie A. Liu and Y P Liu and Curtis D. Klaassen},
  journal={Toxicology letters},
  year={1996},
  volume={87 2-3},
  pages={139-45}
}
Metallothionein (MT) has been proposed to play an important role in heavy metal detoxication and in the scavenging of free radicals. Effects of MT on the cytotoxicity of cadmium (Cd), tert-butylhydroperoxide (t-BHP) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were examined using primary hepatocyte cultures from control (C57BL/6J) and MT-I and II knock-out (MT-null) mice. Compared to control hepatocytes, MT-null hepatocytes had minimal Cd-binding proteins (MT equivalents), but cellular… CONTINUE READING
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