Hepatocytes as a source of cholangiocytes in injured liver.


Cellular reprogramming—the ability to interconvert distinct cell types with defined factors—is transforming the field of regenerative medicine. However, this phenomenon has rarely been observed in vivo without exogenous factors. Here, we report that activation of Notch, a signaling pathway that mediates lineage segregation during liver development, is… (More)
DOI: 10.1002/hep.26673


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