Hepatocyte transplantation into the lung for treatment of acute hepatic failure in the rat.

@article{Then1991HepatocyteTI,
  title={Hepatocyte transplantation into the lung for treatment of acute hepatic failure in the rat.},
  author={P. K. Then and P. Sandbichler and R. Erhart and Otto Dietze and G{\"u}nther Klima and Wolfgang Vogel and Raimund Margreiter},
  journal={Transplantation proceedings},
  year={1991},
  volume={23 1 Pt 1},
  pages={892-3}
}
The lung was investigated as a matrix for transplanted hepatocytes in the rat model. Surgically induced fulminant hepatic failure was successfully treated by injection of 5 to 7 x 10(7) isolated hepatocytes into the pulmonary parenchyma in 86% of the animals. No animal, however, survived injection of hepatocytes into the jugular vein. It was found that… CONTINUE READING