Hepatocyte transplantation in acute liver failure.

@article{Bilir2000HepatocyteTI,
  title={Hepatocyte transplantation in acute liver failure.},
  author={Bahri M Bilir and D Guinette and Frederick R Karrer and David A. Kumpe and J Krysl and Janet Stephens and Loris McGavran and Alina Ostrowska and Janette Durham},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  year={2000},
  volume={6 1},
  pages={32-40}
}
The majority of patients with acute liver failure (ALF) die waiting for orthotopic liver transplantation (OLT). No other treatment modality is shown to improve survival. This study was conducted to assess the safety and feasibility of hepatocyte transplantation (HT) and subsequent engraftment and function of donor cells. Functional and structural integrity of cryopreserved and thawed human hepatocytes were assessed by their morphological characteristics, induction of P-4501A1 transcription, and… CONTINUE READING

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