Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donor cells

@article{Braun2000HepatocyteTI,
  title={Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donor cells},
  author={Kristin M. Braun and Jay L. Degen and Eric P. Sandgren},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={320-326}
}
To provide long-term therapy in patients with severe toxin-induced hepatic parenchymal damage, donor hepatocytes would need to replicate and replace a large portion of the damaged parenchyma. Using a mouse model developed to reproduce this type of hepatic injury, we found that hepatocyte transplantation only slightly improved survival after transplantation despite the fact that many non-survivors showed moderate liver repopulation by donor cells. Perhaps accounting for this outcome, donor… CONTINUE READING

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Hepatocyte transplantation

  • J. R. Chowdhury
  • N . Engl . J . Med .
  • 1998

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