Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase.

@article{Hasselblatt2007HepatocyteSI,
  title={Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase.},
  author={Peter Hasselblatt and Martina Rath and Vukoslav Komnenovic and Kurt Zatloukal and Erwin F Wagner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 43},
  pages={17105-10}
}
Analysis of the molecular factors determining hepatocyte survival or death in response to inflammatory stimuli is essential for understanding the pathogenesis of inflammatory liver disease and for identifying novel therapeutic approaches. c-Jun N-terminal kinase (JNK) is a major mediator of cytokine-induced cell death during hepatitis, but the signaling pathways downstream of JNK remain less well defined. Here we show that the transcription factor c-Jun/AP-1, a prototypic target of JNK, is… CONTINUE READING

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