Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy.

@article{Chaisson2002HepatocytespecificIO,
  title={Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy.},
  author={Michelle L. Chaisson and John T Brooling and Warren C. Ladiges and Sophia Y. Tsai and Nelson Fausto},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 2},
  pages={193-202}
}
One of the earliest TNF-dependent events to occur during liver regeneration is the activation of the transcription factor NF-kappaB through TNF receptor type 1. NF-kappaB activation in the liver can have both antiapoptotic and proliferative effects, but it is unclear which liver cell types, hepatocytes or nonparenchymal cells (NPCs), contribute to these effects. To specifically evaluate the role of hepatocyte NF-kappaB, we created GLVP/DeltaN-IkappaB(alpha) transgenic mice, in which expression… CONTINUE READING
59 Extracted Citations
34 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 59 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 34 references

NF-κB determines between apoptosis and proliferation in hepatocytes during liver regeneration

  • J Plumpe
  • Am. J. Physiol. Gastrointest. Liver Physiol. 278…
  • 2000

Similar Papers

Loading similar papers…