Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress

  title={Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress},
  author={Irina M Bochkis and Nir E Rubins and Peter White and Emma Elizabeth Furth and Joshua R Friedman and Klaus H. Kaestner},
  journal={Nature Medicine},
Production of bile by the liver is crucial for the absorption of lipophilic nutrients. Dysregulation of bile acid homeostasis can lead to cholestatic liver disease and endoplasmic reticulum (ER) stress. We show by global location analysis ('ChIP-on-chip') and cell type–specific gene ablation that the winged helix transcription factor Foxa2 is required for normal bile acid homeostasis. As suggested by the location analysis, deletion of Foxa2 in hepatocytes in mice using the Cre-lox system leads… CONTINUE READING
66 Citations
60 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 66 extracted citations


Publications referenced by this paper.
Showing 1-10 of 60 references

Beneficial effect of spironolactone administration on ethynylestradiol - induced cholestasis in the rat : involvement of up - regulation of multidrug resistance – associated protein 2

  • M. L. Ruiz
  • Drug Metab . Dispos .
  • 2007

involvement of up-regulation of multidrug resistance– associated protein 2

  • Ruiz, M. L. et al. Beneficial effect of spironolactone admi rat
  • Drug Metab. Dispos. 35, 2060–2066
  • 2007

a transcription factor which regulates epididymis-specific gene expression

  • Suzuki, K. et al. Epididymis-specific promoter–driven gene targeting
  • Mol. Cell. Endocrinol. 250, 184–189
  • 2006

Similar Papers

Loading similar papers…